What does ivermectin do to the brain?

Ivermectin Iverheal 12mg is an antiparasitic drug primarily used to treat infections caused by parasites like river blindness (Onchocerciasis), strongyloidiasis, and scabies. It works by targeting glutamate-gated chloride channels in parasites, causing paralysis and death. However, its effects on the human brain depend on dosage, blood-brain barrier integrity, and individual sensitivity.

In humans, the blood-brain barrier (BBB) prevents ivermectin from entering the central nervous system in significant amounts. However, in rare cases, especially with high doses or genetic predispositions, ivermectin can cross the BBB and interact with GABA receptors in the brain, potentially leading to neurotoxicity.